Weishuo Fang
Institute of Materia Medica, China
Biography
Weishuo Fang has graduated from Peking Union Medical College and awarded PhD degree in 1997. After two years' of Post-doctoral study in Florida State University, USA, he started his independent career in Institute of Materia Medica, Chinese Academy of Medical Sciences as a Professor. The major theme of his research lab in is medicinal chemistry and chemical biology of bioactive natural products. Two research directions have been actively pursued by him in the past decade: Drug discovery against three distinct targets, including microtubule (protein-protein interaction), beta-secretase (enzyme) and farnesoid X receptor (nuclear receptor), to pursue therapeutic agents with new chemo types and/or with superior activity; and construction of a natural product-inspired library based on the privileged structure concept and its application to drug discovery to improve the efficiency of hit/lead discovery.
Abstract
Abstract : Natural products based FXR antagonists: From plant constituents to in vivo active molecules