Hye Jin Jung
Sun Moon University, Korea
Title: Anticancer activity and mechanism of action of a novel nargenicin A1 derivative
Biography
Biography: Hye Jin Jung
Abstract
Discovery of novel biologically active natural products and understanding their modes of action are crucial processes for their development into clinical drugs. The goal of this study is to explore a new natural lead compound for anticancer therapy. Nargenicin A1 is an effective antibacterial compound produced by Nocardia spp. CS682 and exhibits significant activity against various Gram-positive bacteria. Recently, novel derivatives of nargenicin A1 were created using a synthetic biology platform. In this study, we performed comparative analysis of the anticancer activities of nargenicin A1 and its derivatives. Among them, an analog significantly suppressed the growth and metastasis of cancer cells. Therefore, this study evaluates in vitro and in vivo anticancer effect of a novel nargenicin A1 derivative as well as deciphers its cellular action mechanism.