Haseeb Ahsan
University of Sargodha, Pakistan
Title: Anti-inflammatory, analgesic and antipyretic activities of the aqueous methanolic extract of Berberis calliobotrys in albino mice
Biography
Biography: Haseeb Ahsan
Abstract
The aqueous methanolic extract of stem part of Berberis calliobotrys were evaluated for anti-inflammatory, analgesic and antipyretic activities in albino mice. Anti-inflammatory activity was evaluated by using carrageenan and albumin induced paw oedema, while the analgesic effect was assessed by using formalin-induced paw licking and acetic acid induced abdominal writhing in mice. The brewer’s yeast-induced pyrexia model was used for antipyretic investigation. Ibuprofen (40 mg/kg) was used as a standard drug in all the three models. The crude extract at both (250 mg/kg and 500 mg/kg) doses, showed highly significant (p < 0.001) reduction in paw oedema induced by carrageenan and albumin. Moreover, the extract also highly significantly (p<0.001) reduced (87%) the formalin-induced paw licking at 500mg/kg. The highly significant (p<0.001) reductions (24.48 % and 37.9 %) was also observed in the number of writhes. Furthermore, extract also demonstrated significant (p < 0.001) antipyretic activity against yeast induced pyrexia. The maximum effect was observed in all the three parameters at 500 mg/kg dose. The results suggest a potential benefit of the aqueous methanolic extract of Berberis calliobotrys in treating conditions associated with inflammation, pain and fever.