Pushpander Kumar
Kurukshetra University, India
Title: Antidiabetic activity of Acacia leucophloea stem bark in streptozotocin-nicotinamide induced type-2 diabetic rat model
Biography
Biography: Pushpander Kumar
Abstract
Introduction: In 2014, 9% of adults 18 years and older had diabetes (a WHO report, 2015). In 2012, diabetes was the straight reason of 1.5 million deaths worldwide with 80% of diabetes deaths in low/middle revenue countries. World Health Organization (WHO) projecting diabetes will be the 7th prominent cause of death in 2030. Objective: Aim of the present research work was to examine the anti-diabetic activity of hydroalcoholic stem bark extract of Acacia leucophloea (HAALE) in streptozotocin-nicotinamide induced type-2 induced diabetes model. Method: In streptozotocin-nicotinamide induced diabetic rats model were treated by administering oral doses (250 and 500 mg/kg body weight) of HAALE and standard glicazide (10 mg/kg) for 21 days. Blood glucose levels were measured using glucometer on different time duration i.e., day 0, 7, 14 and 21 days. Other biochemical parameters (LDL, VLDL, Triglycerides, Urea, HDL, and total cholesterol) were determined in normal and streptozotocin-nicotinamide induced diabetic rats after oral administration of extract for 21 days. Histopathological changes in diabetic rat’s organs (pancreas, liver and kidney) were observed under the microscope after extract treatment. Result: Daily oral administration of HAALE (250 and 500 mg/kg) and glicazide (10 mg/kg) showed significant (p<0.01) reduction in blood glucose level as well as improving kidney, liver functions and hyperlipidemia due to diabetes in control rat. Furthermore, the extract has encouraging effects on the histopathological changes in pancreas, liver and kidney in streptozotocin-nicotinamide induced diabetes. Conclusion: Hydroalcoholic extract (500 mg/kg) of Acacia leucophloea was found to have potential anti-diabetic activity in comparison with 250 mg/kg with well improved parameters such as LDL, VLDL, Triglycrides, Urea, HDL and total cholesterol. HAALE has also favorable effect to inhibit the histopathological changes of the pancreas and kidney in streptozotocin-nicotinamide induced diabetes model.