Karl Charlene Calderon
University of Santo Tomas, Philippines
Title: Durio zibethinus L. (Malvaceae) Seed Gum: Extraction, Characterization, and Evaluation as Paracetamol Tablet Binder
Biography
Biography: Karl Charlene Calderon
Abstract
Durio zibethinus L. (Malvaceae) known as “Durian†in the Philippines is an evergreen tropical tree found vastly in the regions of Mindanao and Sulu. One-fourth of the fruit's mass is the seeds, which is usually discarded. This study aimed to determine the binding efficacy of extracted Puyat variety of Durian seed gum in Paracetamol tablet formulation. Durian seed gum was extracted and characterized in terms of its physicochemical properties. An acute oral toxicity study was done. Differential Scanning Calorimeter was used to test the compatibility of Durian seed gum with Paracetamol and tablet excipients. Different batches of Paracetamol tablet was formulated using Durian seed gum, PVP K-30, Acacia, and Corn starch as binder. Physical evaluation was done on Paracetamol granules and comparative analysis showing the effectiveness of Durian seed gum in contrast with standard binders was evaluated through quality control tests like hardness, friability, disintegration, and dissolution test. The result of the study showed that Durian seed gum possesses good physicochemical properties. It is non-toxic and compatible with Paracetamol and its excipient. The formulation containing 9% w/w of unheated Durian seed gum as binder showed good binding efficacy with a friability of 0.74%. It displayed the highest dissolution rate (101.3%). The results suggest that it can be used as binder in immediate released tablets. Whereas, 9% w/w heated Durian seed gum exhibited highest binding efficacy with a friability of 0.15% and a hardness of 184.87N. The result shows that it can be used as a binder for sustained released tablets.