Vanderlan da Silva Bolzani
São Paulo State University, Brazil
Title: Orbitides and cyclotides from Brazilian plant species: An unexplored source of new biologically active compounds
Biography
Biography: Vanderlan da Silva Bolzani
Abstract
The huge Brazilian biodiversity holds a tremendous resource of natural products. However, this fantastic chemical diversity still has been completely unexplored, representing vast and complex structural diversity of unknown peptides (orbitides and cyclotides), which are inspirations for advanced research of tropical and equatorial plant species and also are the sources of raw material for the discovery of new molecular targets that constitute valuable set of leads useful for further medicinal chemistry research. Our recent investigations on species of Jatropha (Euphorbiaceae); Hybanthus and Noisettia (Violaceae) have resulted in several biologically active orbitides and cyclotides, respectively, some of these presented potent cell migration inhibitions. These compounds are interesting classes of metabolites due to their structural features and pharmacological properties. This work deals with the isolation, synthesis and structure elucidation of new orbitides from J. ribifolia, J. molissima and J. curcas. Additionally, from Hybanthus calceolaria (roots) and Noisettia orchidiflora (stems, leaves and roots) several novel cyclotides were isolated and its inhibition of migration cell was evaluated by wound healing test. Additionally, some studies on the function of these compounds in these species are being performed using MALDI imaging mass spectrometry (MALDI-IMS) and will be presented.