Rama Swamy Nanna
Kakatiya University, India
Title: Screening of new ethnomedicinal properties of aqueous leaf extracts of Senna alata
Biography
Biography: Rama Swamy Nanna
Abstract
The species Senna alata L. Roxb (Fabaceae), commonly known as Ringworm Senna or Candle Brush Tree or Seven Golden Candle Sticks is an important medicinal and ornamental plant. The plant parts are used in the treatment of intestinal parasites, ringworm, scabies, eczema, tinea infections, itches, insect bites, and herpes. A set of pharmacological parameters of aqueous leaf extracts of the species were determined. Acute toxicity studies were conducted till a dose of 5000 mg/Kg which found to be safe without causing any side effects or change in the behavioural patterns of the animals. However, a dose of 200 mg/Kg body weight was selected for the present study. In the present investigation, antidiabetic activity of aqueous leaf extracts of S. alata also has been carried out in alloxan induced diabetes in rats. The decrease in both the parameters i.e., fasting and post treatment glucose level the blood glucose levels were comparable to that of the standard drug Glibenclamide (10 mg/kg). The antihyperglycemic effect of S. alata on post treated blood glucose levels in the diabetic rats was assessed on 1st, 7th and 15th day. There was also a decrease in the hyper lipedimic profile associated with diabetes i.e., total cholesterol, HDL, LDL and triglyceride levels in the test group on the 15th day in alloxan induced diabetic rats. From this it was experimentally proved that the plant can be used as a potent drug preparation for treatment of diabetes in experimental rats and the use of this plant in Human diabetes will be discussed.