Rongshi Li
University of Nebraska Medical Center, USA
Title: Unique Drug Discoveries Based on Marinopyrrole and Novel Derivatives
Biography
Biography: Rongshi Li
Abstract
Natural products and their derivatives account for about half of the New Chemical Entities (NCEs) for drug discovery to treat human diseases. For example, 78 of the 118 small-molecule NCEs identified for antibacterial agents were from either natural products or their derivatives during 30 years between 1981 and 2010. For anticancer drug discoveries, 85 of the 175 small molecules, for 70-year span from 1940 to 2010, were from natural products, their derivatives, metabolites and mimics [Newman, DJ and Cragg, GM. J. Nat. Prod. 2012, 75, 311]. To date, natural products have provided the most successful supply of drug leads (Li, R. Med. Res. Rev. 2016, 36, 169]. In this talk, a case study of marinopyrrole and its novel derivatives as potential antibiotic and anticancer agents will be presented. The design, synthesis and optimization of these novel derivatives to achieve improved physicochemical and drug-like properties, and potent biological activities and high selectivity with low toxicity will be discussed.
