Hye-Jin Kim
Korea Institute of Oriental Medicine, Korea
Title: Effect of the 70% ethanol extract of Tetragonia tetragonioides on immunoreactivity in ovariectomized mouse model
Biography
Biography: Hye-Jin Kim
Abstract
Statement of the Problem: Women who have experienced menopause are at greater risk for immune imbalance including hormone problem. Estrogens are involved in immune response at least of the humoral immunity and androgens and progesterone. However, hormone replacement therapy has limitations of breast cancer incidence. Herbal medicines, which have less adverse effects, have received attention to compensate for the problems related to hormone replacement therapy. The purpose of this study is to demonstrate the immunological efficacy of T. tetragonioides (TT) using ovariectomized animal models.
Methodology & Theoretical Orientation: TT has been used for improving women’s health and treating inflammatory diseases. The sequencing analysis from the nuclear genome makes the internal transcribed spacer region a valuable resource for plant species identification. We sought to investigate the effects of TT the level of inflammation markers (IL-1β, IL-6, IL-12, IL-17 and IFN-γ) using ovariectomized mice.
Findings: As a result of ITS gene analysis, 20 individuals collected from different region showed 99% homology. IL-1β, IL-2, ILâ€12, ILâ€17, and IFNâ€γ in CD4+T cells were significantly reduced in ovariectomized animal model. It also showed an increase in anti-inflammatory cytokines (IL-10). In addition, they displayed significant immuno modulating activities including inhibition of generation of TNF-α, ILâ€1β and IL-12 of immune cell cytokine production in mesenteric lymph node, whereas increased the cytokine of IL-4 and IL10.
Conclusion & Significance: These results suggest to target the modulation of inflammatory immune responses for the treatment of menopausal symptoms and related diseases.