Slobodan Dunjić
Center for Integrative procedures and Supplements, Serbia
Title: Some biochemical parameters and their relation with elevation of ovary tumor marker – our experience
Biography
Biography: Slobodan Dunjić
Abstract
Introduction: Along with the conventional methods for diagnostics and treatment, holistic-personalized medicine consolidates all scientifically validated alternative methods of treatments and healing. Holistic approach uses natural products for healing.
Aim: The aim of the paper is to present the relation that we found between ovary tumor marker CA-125 and some biochemical parameters.
Materials & Methods: 130 females were included in the study, with the minimum age being 24 years and maximum 79 years. Mean age was 45.42±13.12yrs. Laboratory analysis of female patients was statistically analyzed. Patients were divided into two groups: group with level of CA-125 within normal range (NR value: 0–35 U/mL), and patients having elevated levels of CA-125 (EV value: over 35 U/mL). None of the patients were diagnosed with ovarian tumor. All of patients were recruited from the Center for Integrative Procedures and Supplements “Dr Dunjić”, Belgrade. Holistic-personalized approach in patients healing was performed in the center and statistical analysis was done by using the Statistical Package for the Social Sciences (SPSS).
Results: Numerous biochemical parameters have shown statistically significant difference between two groups examined—NR vs. EV of CA-125. Prolactin was 390.19±20.36 vs. 718.0±18.37; p=0.045; df=17. Cortisol level was 485.95±16.7 vs. 1.100,3±91.8; p=0.001; df=32. Liver enzyme Aspartate Aminotransferase (AST) level was 22.8±12.6 vs. 40.0±16.1; p=0,047; df=23. Liver enzyme gama-GT was 19.11±3.48 vs. 55.5±6.16; p=0,025; df=17. Tumor marker alpha fetoprotein was 3.8±2.2 vs. 8.65±1.34; p=0,013; df=13. Level of oxidative damage marker 8-hydroxy-2'-deoxyguanosine (8-OHdG) was 17.64±5.8 vs. 20.25±6.8; p=0,007; df=6. Vitamin D was higher in NR group, but did not show statistical significant difference between two groups examined—53.42±22.5 vs. 41.9±11.0; p=0.173; df=77.
Conclusion: These finding also point that imbalance in the human body, which is represented with CA-125 elevation, can be accompanied with numerous biochemical changes. That is true for hormones (i.e. prolactin, cortisol), AST, gama-GT, alpha fetoprotein and 8-OHdG. However, the clinical importance of these findings requires further research.