Biography
InWha Park is a Graduate from the Department of Herbal Resources at Joongbu University, South Korea and has completed her Master’s Degree from the College of Pharmacy at Chungnam National University, South Korea. She has studied in the Pharmacognosy Laboratory at the College of Pharmacy, Chungnam National University. Her research interest is in the isolation and structure determination of secondary metabolites from natural products that include insects and marine organisms.
Abstract
Recently, researches for novel food and medicinal materials have focused on insect resources. Grasshoppers (Oxya chinensis sinuosa Mistshenko) have been utilized as an edible insect in Asia and have been used to treat cough, asthma, bronchitis, paralysis and seizures. The aim of this study was to identify previously unreported bioactive anti-platelet compounds from this insects. Chemical investigation of the O. chinensis sinuosa led to the isolation of two new and known N-acetyldopamine dimers. The structures of compounds including absolute configurations were determined by 1D and 2D NMR, High-resolution electrospray ionisation mass spectrometry (HRESIMS) and Circular dichroism (CD) spectroscopic data analysis. All isolated compounds were evaluated for their anticoagulant activity by monitoring clotting and bleeding time, the activated partial thromboplastin time (aPTT) and Prothrombin time (PT). Compounds were shown to have platelet aggregation inhibitory activities. Collectively, these results show that compounds could serve as candidates and provide scaffolds for the development of new anti-platelet drugs.
Biography
DaYoung Kim is a Graduate from the Department of Chemistry at Mokwon University, South Korea. She works at the Pharmacognosy Laboratory of the Colloge of Pharmacy, Chungnam National University, South Korea. She has recently published a paper in Korean Journal of Aesthetics and Cosmetology
Abstract
The plant M. charantia L., called “bitter melon†is widely cultivated in Asian countries. It is commonly used as a vegetable and medicine. The extract of the fruit of this plant was shown to posses anti-helmintic, antibacterial, antifertility, antidiabetic, as well as antiproliferative activities. The aim of this study was to identify the unreported six new cucurbitane-type triterpenoids from the fruits of M. charantia, utilizing diverse chromatographic and spectroscopic techniques. In particular, the 2D structure of 1 was confirmed utilizing the long-range HSQMBC NMR pulse, capable of measuring heteronuclear longrange correlations (4-6JCH). The cucurbitanes were also assessed for their inhibitory activity against Platelet-derived growth factor (PDGF)-induced Vascular smooth muscle cells (VSMC) proliferation. In particular, 2 and 4 at 10 μM curbed the VSMC proliferation by 72.4% and 67.9%, respectively, demonstrating significant inhibitory activity among the tested phytochemicals. This study may constitute a basis for developing those chemotypes into sensible pharmacophores alleviating cardiovascular disorders.